CA I Polyclonal Antibody
Ucallm_WP11348-50
Price range: $268.00 through $328.00
Product details
Background:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Specifications
| Size | 50μL/100μL |
| Target | CA I |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 29kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CA1. AA range:41-90 |
| Specificity | CA I Polyclonal Antibody detects endogenous levels of CA I protein. |
| Gene Name | CA1 |
| Protein Name | Carbonic anhydrase 1 |
| Other Name | CA1; / Carbonic anhydrase 1; / Carbonate dehydratase I; / Carbonic anhydrase B; / CAB; / Carbonic anhydrase I; / CA-I |
| Species | Human |
| Gene ID | 759 |
| Uniprot | P00915, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P13634 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Pancreas,Spleen, |
| Signaling_pathway | |
| Research Areas | >>Nitrogen metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,Function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family., |
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