CABP Polyclonal Antibody
Ucallm_WP5903-50
Price range: $268.00 through $328.00
Product details
Background:
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1, 4, 5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012],
Specifications
| Size | 50μL/100μL |
| Target | CABP |
| Reactivity | Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of CABP |
| Specificity | The antibody detects endogenous CABP protein |
| Gene Name | CABP1 |
| Protein Name | Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) |
| Other Name | Calcium-binding protein 1; / CaBP1; / Calbrain; / Caldendrin |
| Species | Human |
| Gene ID | 9478 |
| Uniprot | Q9NZU7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JLK7, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O88751 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus . Cell junction, synapse, postsynaptic density . L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane. .; [Isoform L-CaBP1]: Cytoplasm, cytoskeleton . L-CaBP1 is associated most likely with the cytoskeletal structures. .; [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor . S-CaBP1 is localized at or near the plasma membrane. |
| Tissue Expression | Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum. |
| Signaling_pathway | |
| Research Areas | |
| Function | Alternative products:Experimental confirmation may be lacking for some isoforms,similarity:Contains 4 EF-hand domains.,subcellular location:L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.,subunit:Interacts with MYO1C.,tissue specificity:Retina and brain. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum., |
Please login to post questions
Related products
