Price range: $268.00 through $328.00
Background:
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011],
| Size | 50μL/100μL |
| Target | CACNB3 |
| Reactivity | Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1000; IHC 1:200-500; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of CACNB3 |
| Specificity | The antibody detects endogenous CACNB3 protein. |
| Gene Name | CACNB3 |
| Protein Name | Voltage-dependent L-type calcium channel subunit beta-3 |
| Other Name | CACNB3; / CACNLB3; / Voltage-dependent L-type calcium channel subunit beta-3; / CAB3; / Calcium channel voltage-dependent subunit beta 3 |
| Species | Human |
| Gene ID | 784 |
| Uniprot | P54284, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P54285, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P54287 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed mostly in brain, colon and ovary. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>Oxytocin signaling pathway; / >>Hypertrophic cardiomyopathy; / >>Arrhythmogenic right ventricular cardiomyopathy; / >>Dilated cardiomyopathy |
| Function | Function:The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.,similarity:Belongs to the calcium channel beta subunit family.,similarity:Contains 1 SH3 domain.,subunit:The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4.,tissue specificity:Expressed mostly in brain, smooth muscle and ovary., |
