SKU: WP11371 Categories: ,

Cadherin-22 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11371-100
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Product details

Background:

This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCadherin-22
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)84kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CDH22. AA range:111-160
SpecificityCadherin-22 Polyclonal Antibody detects endogenous levels of Cadherin-22 protein.
Gene NameCDH22
Protein NameCadherin-22
Other NameCDH22; / C20orf25; / Cadherin-22; / Pituitary and brain cadherin; / PB-cadherin
SpeciesHuman
Gene ID64405
UniprotQ9UJ99,
Species.1Mouse
Gene ID.1
Uniprot.1Q9WTP5,
Species.2Rat
Gene ID.229182
Uniprot.2Q63315
Cellular LocalizationCell membrane; Single-pass type I membrane protein .
Tissue ExpressionBrain,Testis,
Signaling_pathway
Research Areas
FunctionFunction:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.,similarity:Contains 5 cadherin domains.,
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