SKU: WP15283 Categories: ,

Calbindin D28K Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15283-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015],

Specifications

Size50μL/100μL
TargetCalbindin
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)30kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human CALB1. AA range:191-240
SpecificityCalbindin Polyclonal Antibody detects endogenous levels of Calbindin protein.
Gene NameCALB1
Protein NameCalbindin
Other NameCALB1; / CAB27; / Calbindin; / Calbindin D28; / D-28K; / Vitamin D-dependent calcium-binding protein, avian-type
SpeciesHuman
Gene ID793
UniprotP05937,
Species.1Mouse
Gene ID.112307
Uniprot.1P12658,
Species.2Rat
Gene ID.283839
Uniprot.2P07171
Cellular Localizationnucleus,cytosol,axon,dendrite,neuronal cell body,terminal bouton,synapse,extracellular exosome,
Tissue ExpressionBrain,Cerebellum,Kidney,Lung,Substantia nigra,
Signaling_pathway
Research Areas>>Endocrine and other factor-regulated calcium reabsorption
FunctionDomain:This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.,Function:Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.,online information:Calbindin entry,similarity:Belongs to the calbindin family.,similarity:Contains 5 EF-hand domains.,subunit:Interacts with RANBP9.,
Please login to post questions
Back to Top
Product has been added to your cart