Calbindin D28K Polyclonal Antibody
Ucallm_WP15283-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015],
Specifications
| Size | 50μL/100μL |
| Target | Calbindin |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 30kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CALB1. AA range:191-240 |
| Specificity | Calbindin Polyclonal Antibody detects endogenous levels of Calbindin protein. |
| Gene Name | CALB1 |
| Protein Name | Calbindin |
| Other Name | CALB1; / CAB27; / Calbindin; / Calbindin D28; / D-28K; / Vitamin D-dependent calcium-binding protein, avian-type |
| Species | Human |
| Gene ID | 793 |
| Uniprot | P05937, |
| Species.1 | Mouse |
| Gene ID.1 | 12307 |
| Uniprot.1 | P12658, |
| Species.2 | Rat |
| Gene ID.2 | 83839 |
| Uniprot.2 | P07171 |
| Cellular Localization | nucleus,cytosol,axon,dendrite,neuronal cell body,terminal bouton,synapse,extracellular exosome, |
| Tissue Expression | Brain,Cerebellum,Kidney,Lung,Substantia nigra, |
| Signaling_pathway | |
| Research Areas | >>Endocrine and other factor-regulated calcium reabsorption |
| Function | Domain:This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.,Function:Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.,online information:Calbindin entry,similarity:Belongs to the calbindin family.,similarity:Contains 5 EF-hand domains.,subunit:Interacts with RANBP9., |
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