Calgizzarin Polyclonal Antibody
Ucallm_WP11382-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | S100A11 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 12kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Calgizzarin . at AA range: 30-110 |
| Specificity | Calgizzarin Polyclonal Antibody detects endogenous levels of Calgizzarin protein. |
| Gene Name | S100A11 |
| Protein Name | Protein S100-A11 |
| Other Name | S100A11; / MLN70; / S100C; / Protein S100-A11; / Calgizzarin; / Metastatic lymph node gene 70 protein; / MLN 70; / Protein S100-C; / S100 calcium-binding protein A11 |
| Species | Human |
| Gene ID | 6282 |
| Uniprot | P31949, |
| Species.1 | Mouse |
| Gene ID.1 | 20195 |
| Uniprot.1 | P50543, |
| Species.2 | Rat |
| Gene ID.2 | 445415 |
| Uniprot.2 | Q6B345 |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Brain,Epithelium,Keratinocyte,Lung,Mammary carcinoma,Placenta,Urina |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Facilitates the differentiation and the cornification of keratinocytes.,miscellaneous:Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.,PTM:Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer; disulfide-linked., |
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