Price range: $268.00 through $328.00
Background:
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CaMKIV |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 9E8 |
| Immunogen | Purified recombinant human CaMKIV protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CaMKIV and does not cross-react with related proteins. |
| Gene Name | camk4 |
| Protein Name | |
| Other Name | Brain Ca; / 2; / calmodulin dependent protein kinase type 4; / Brain Ca; / 2; / calmodulin dependent protein kinase type IV; / Brain Ca -calmodulin dependent protein kinase type IV; / Calcium / calmodulin dependent protein kinase type 4 catalytic chain; / Calcium / calmodulin dependent protein kinase type IV catalytic chain; / Calcium/calmodulin dependent protein kinase IV; / Calcium/calmodulin dependent protein kinase type IV; / Calcium/calmodulin-dependent protein kinase type IV; / CAM kinase 4; / CAM kinase GR; / CAM kinase IV; / CAM kinase-GR; / CaMK 4; / CAMK GR; / CaMK IV; / CaMK4; / CaMKGR; / IV; / KCC4_HUMAN; / MGC36771. |
| Species | Human |
| Gene ID | 814 |
| Uniprot | Q16566, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P08414 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). . |
| Tissue Expression | Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Organismal Systems >> Aging >> Longevity regulating pathway;Human Diseases >> Cancer: specific types >> Glioma;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>cAMP signaling pathway; / >>Longevity regulating pathway; / >>Apelin signaling pathway; / >>Osteoclast differentiation; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Cholinergic synapse; / >>Oxytocin signaling pathway; / >>Aldosterone synthesis and secretion; / >>Amphetamine addiction; / >>Alcoholism; / >>Glioma |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,Function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.,PTM:Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.,subunit:Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.,tissue specificity:Expressed in epithelial ovarian cancer tissue., |
