$999.00
Carboxymethyl Lysine Specific Antibody Conjugated Agarose Beads is developed using carboxymethylated KLH as immunogen, and affinity purified with CML-agarose. The purified CML antibody is chemically linked to beaded agarose through a stable covalent linkage. The immobilized CML antibody-agarose can be utilized for reversible immunoprecipitation and affinity purification of proteins/peptides with carboxymethyl lysine residues.
| Target | Carboxymethyl Lysine |
| Reactivity | Species Independent |
| Application | IAC, IP |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | |
| Conjugate | |
| Modification | |
| Modified site | |
| Recommended dilution ratio | |
| Composition | 500 μL of beads in 1 mL of slurry with 50% glycerol |
| Purification process | |
| Purity | |
| Storage | Product is stable for several weeks at 4°C. For extended storage, store product at –20ºC. Shake it well before use. |
| Stability | Expiration date is 12 months from the date of shipping if properly stored. |
| Clonal | Polyclonal |
| Clone Number | |
| Immunogen | Carboxymethylated KLH |
| Sequence | |
| Specificity | |
| Gene name | |
| Protein Name | |
| Alternative name | |
| Organism-1 | |
| GeneID-1 | |
| SwissProt-1 | |
| Organism-2 | |
| GeneID-2 | |
| SwissProt-2 | |
| Organism-3 | |
| GeneID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| GeneID-4 | |
| SwissProt-4 | |
| Background | Lysine carboxymethylation, also known as carboxymethyllysine (CML), is a typical advanced glycation end product (AGE). It is formed by the non-enzymatic reaction between reducing sugars and the ε-amino group of lysine residues in proteins under oxidative stress and hyperglycemic conditions. This modification changes protein structure, stability and physiological function, and disrupts normal protein-protein interactions.CML accumulates progressively in tissues during aging. Abnormal CML formation and accumulation are closely linked to diabetes, diabetic complications, cardiovascular diseases, neurodegeneration and age-related disorders. |
| Cellular Localization |
