Name: Casein Kinase IIα Polyclonal Antibody
SKU: WP11414
Price: 268 USD
Availability: InStock

Product details

Background:

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014],

Specifications

Target	Casein Kinase IIα
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Casein Kinase II alpha. AA range:221-270
Sequence
Specificity	Casein Kinase IIα Polyclonal Antibody detects endogenous levels of Casein Kinase IIα protein.
Gene Name	CSNK2A1
Protein Name	Casein kinase II subunit alpha
Other Name	CSNK2A1; / CK2A1; / Casein kinase II subunit alpha; / CK II alpha
Species	Human
Gene ID-1	1457
Uniprot	P68400,
Species.1	Mouse
Gene ID-2	12995
Uniprot.1	Q60737,
Species.2	Rat
Gene ID-3	116549
Uniprot.2	P19139
Organism-4
Gene ID-4
SwissProt-4
Background	Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014],
Cellular Localization	Nucleus .
Tissue Expression	Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Research Areas	>>Ribosome biogenesis in eukaryotes; / >>NF-kappa B signaling pathway; / >>Mitophagy - animal; / >>Wnt signaling pathway; / >>Adherens junction; / >>Alzheimer disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Measles; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.,
RRID

Please login to post questions

Casein Kinase IIα Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

Casein Kinase IIα Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® Smad2 (Phospho Ser250) Rabbit mAb

U-Blot® FOXO3A (Phospho Ser253) Rabbit mAb

U-Blot® Tuberin Rabbit mAb

U-Blot® BID Rabbit mAb

U-Blot® CDK6 Rabbit mAb

Acetyl Lysine Monoclonal Antibody [10B10]

Customer Reviews

Menu