CBG Polyclonal Antibody
Ucallm_WP11446-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013],
Specifications
| Size | 50μL/100μL |
| Target | CBG |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 54-58kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GBA3. AA range:291-340 |
| Specificity | CBG Polyclonal Antibody detects endogenous levels of CBG protein. |
| Gene Name | GBA3 |
| Protein Name | Cytosolic beta-glucosidase |
| Other Name | GBA3; / CBG; / CBGL1; / Cytosolic beta-glucosidase; / Cytosolic beta-glucosidase-like protein 1 |
| Species | Human |
| Gene ID | 57733 |
| Uniprot | Q9H227 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . |
| Tissue Expression | Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas. |
| Signaling_pathway | |
| Research Areas | >>Starch and sucrose metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.,enzyme regulation:Inhibited by 2,4-dinitrophenyl-2-fluoro-2-deoxy-beta-D-glucopyranoside and sodium taurocholate.,Function:Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens.,PTM:The N-terminus is blocked.,similarity:Belongs to the glycosyl hydrolase 1 family.,similarity:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,tissue specificity:Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas., |
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