CCL17 Polyclonal Antibody
Ucallm_WP16155-50
Price range: $268.00 through $328.00
Product details
Background:
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014],
Specifications
| Size | 50μL/100μL |
| Target | TARC |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 10kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA(peptide)1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CCL17 AA range: 21-70 |
| Specificity | This antibody detects endogenous levels of human CCL17 |
| Gene Name | CCL17 SCYA17 TARC |
| Protein Name | C-C motif chemokine 17 |
| Other Name | CCL17; / SCYA17; / TARC; / C-C motif chemokine 17; / CC chemokine TARC; / Small-inducible cytokine A17; / Thymus and activation-regulated chemokine |
| Species | Human |
| Gene ID | 6361 |
| Uniprot | Q92583 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed at high levels in thymus and at low levels in the lung, colon and small intestine. |
| Signaling_pathway | Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>C-type lectin receptor signaling pathway; / >>IL-17 signaling pathway |
| Function | Caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8.,Function:Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.,induction:By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.,online information:CCL17 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Expressed at high levels in thymus and at low levels in the lung, colon and small intestine., |
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