Name: CCL18 Polyclonal Antibody
SKU: WP16129
Price: 268 USD
Availability: InStock

Product details

Background:

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014],

Specifications

Size	50μL/100μL
Target	CCL18
Reactivity	Human
Applications	IHC, ELISA
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-200; ELISA(peptide)1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human CCL18 AA range: 1-80
Specificity	This antibody detects endogenous levels of human CCL18
Gene Name	CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18
Protein Name	CCL18
Other Name	C-C motif chemokine 18; / Alternative macrophage activation-associated CC chemokine 1; / AMAC-1; / CC chemokine PARC; / Dendritic cell chemokine 1; / DC-CK1; / Macrophage inflammatory protein 4; / MIP-4; / Pulmonary and activation-regulated chemokine; / Small-inducible cytokine A18; / [Cleaved into: CCL18; / 1-68; / CCL18; / 3-69; / CCL18; / 4-69; / ]
Species	Human
Gene ID	6362
Uniprot	P55774
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.
Signaling_pathway	Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway
Function	Function:Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.,induction:Specifically induced in macrophages by IL-4, IL-13, and IL-10. Expression is inhibited by IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL-4. Strongly induced in several human cell lines, including monocytic U937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB.,mass spectrometry: PubMed:11745396,online information:CCL18 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.,

Please login to post questions

CCL18 Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

CCL18 Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® NLRP3 Rabbit mAb

U-Blot® SQSTM1/p62 Rabbit mAb

U-Blot™ SSPE buffer, pH 7.4

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot® HDAC2 Rabbit mAb

U-Blot® Smad2 (Phospho Ser250) Rabbit mAb

Customer Reviews

Menu