CD138 Polyclonal Antibody
Ucallm_WP15608-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD138 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SDC1. AA range:191-240 |
| Specificity | CD138 Polyclonal Antibody detects endogenous levels of CD138 protein. |
| Gene Name | SDC1 |
| Protein Name | Syndecan-1 |
| Other Name | SDC1; / SDC; / Syndecan-1; / SYND1; / CD138 |
| Species | Human |
| Gene ID | 6382 |
| Uniprot | P18827, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P18828 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein . Secreted . Secreted, extracellular exosome . Shedding of the ectodomain produces a soluble form. . |
| Tissue Expression | Dermoid cancer,Fibroblast,Kidney,Mammary gland,Placenta, |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>ECM-receptor interaction; / >>Cell adhesion molecules; / >>Malaria; / >>Proteoglycans in cancer; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.,similarity:Belongs to the syndecan proteoglycan family.,subunit:Interacts with CDCP1., |
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