Price range: $268.00 through $328.00
Background:
CD141 is a 75 kDa transmembrane glycoprotein expressed in many normal tissues, such as arterial and venous endothelial cells and mesothelial cells. CD141 is not expressed in liver adenocarcinoma. CD141 protein is a sensitive marker of lymphatic endothelial cells and their tumors. It can be used to distinguish lung adenocarcinoma from malignant mesothelioma.
| Size | 50μL/100μL |
| Target | CD141 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 62kD |
| MW(Observed) | 100kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM145 |
| Immunogen | Synthesized peptide derived from human CD141 AA range: 50-150 |
| Specificity | The antibody can specifically recognize human CD141 protein. |
| Gene Name | THBD THRM |
| Protein Name | CD141 |
| Other Name | AHUS 6; / AHUS6; / BDCA 3; / BDCA3; / CD 141; / CD141; / CD141 antigen; / Fetomodulin; / Thbd; / THPH12; / THRM; / Thrombomodulin; / TM; / TRBM_HUMAN |
| Species | Human |
| Gene ID | 7056 |
| Uniprot | P07204 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Endothelial cells are unique in synthesizing thrombomodulin. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | >>Complement and coagulation cascades; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Fluid shear stress and atherosclerosis |
| Function | Disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,Function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Endothelial cells are unique in synthesizing thrombomodulin., |
