Name: CD19 Monoclonal Antibody
SKU: WM0087
Price: 268 USD
Availability: InStock

CD19 Monoclonal Antibody

Ucallm_WM0087-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM0087-50

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Product details

Background:
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CD19
Reactivity	Human
Applications	IF, FC, ELISA
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications;
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	17E7
Immunogen	Purified recombinant fragment of human CD19 expressed in E. Coli.
Specificity	CD19 Monoclonal Antibody detects endogenous levels of CD19 protein.
Gene Name	CD19
Protein Name	B-lymphocyte antigen CD19
Other Name	CD19; / B-lymphocyte antigen CD19; / B-lymphocyte surface antigen B4; / Differentiation antigen CD19; / T-cell surface antigen Leu-12; / CD antigen CD19
Species	Human
Gene ID	930
Uniprot	P15391,
Species.1	Mouse
Gene ID.1
Uniprot.1	P25918
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Membrane raft; Single-pass type I membrane protein .
Tissue Expression	Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>PI3K-Akt signaling pathway; / >>Hematopoietic cell lineage; / >>B cell receptor signaling pathway; / >>Epstein-Barr virus infection; / >>Primary immunodeficiency
Function	Disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,Function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,