Name: CD19 [PTR1382] recombinant mouse mAb
SKU: WM1235
Price: 268 USD
Availability: InStock

Product details

Background:
CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors.This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Specifications

Size	50μL/100μL
Target	CD80
Reactivity	Human
Applications	FC, ELISA
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	Please check the information on the tube
Clonality	Monoclonal
Clone Number	RMMR1379
Immunogen	Purified recombinant Human CD19
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD19 protein.
Gene Name	CD19
Protein Name	B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
Other Name	B-lymphocyte antigen CD19; / Cd19; / Differentiation antigen CD19; / CD19; / Antibody deficiency due to defect in CD19 antibody; / Antibody deficiency due to defect in CD19; / included antibody; / AW495831 antibody; / B lymphocyte antigen CD19 antibody; / B lymphocyte surface antigen B4 antibody; / B-lymphocyte antigen CD19 antibody; / B-lymphocyte surface antigen B4 antibody; / B4 antibody; / CD19 antibody; / CD19 antigen antibody; / CD19 molecule antibody; / Cd19 protein antibody; / CD19_HUMAN antibody; / CVID3 antibody; / Differentiation antigen CD19 antibody; / Leu 12 antibody; / Leu-12 antibody; / Leu12 antibody; / MGC109570 antibody; / MGC12802 antibody; / T-cell surface antigen Leu-12 antibody
Species	Human
Gene ID	941
Uniprot	P15391,
Species.1	Mouse
Gene ID.1	12519
Uniprot.1	Q00609
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Membrane raft; Single-pass type I membrane protein .
Tissue Expression	Expressed on activated B-cells, macrophages and dendritic cells.
Signaling_pathway	Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Allograft rejection;Human Diseases >> Immune disease >> Graft-versus-host disease;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Cell adhesion molecules; / >>Toll-like receptor signaling pathway; / >>Intestinal immune network for IgA production; / >>Type I diabetes mellitus; / >>Autoimmune thyroid disease; / >>Systemic lupus erythematosus; / >>Rheumatoid arthritis; / >>Allograft rejection; / >>Graft-versus-host disease; / >>Viral myocarditis
Function	Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .

Please login to post questions

CD19 [PTR1382] recombinant mouse mAb

Product details

Specifications

About Us

Support

Order

Menu

CD19 [PTR1382] recombinant mouse mAb

Product details

Specifications

Related products

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot™ Phosphate Buffered Saline with Tween 20 (PBS-T), pH 7.4

U-Blot® Cleaved PARP1 Rabbit mAb

Acetyl Lysine Monoclonal Antibody [10B10]

U-Blot® MMP7 Rabbit mAb

U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

Customer Reviews

Menu