Name: CD20 Monoclonal Antibody
SKU: WM0090
Price: 268 USD
Availability: InStock

CD20 Monoclonal Antibody

Ucallm_WM0090-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM0090-50

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Product details

Background:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CD20
Reactivity	Human
Applications	IHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	4A1
Immunogen	Synthetic peptide corresponding to aa (EPANPSEKNSPSTQY) of human CD20, conjugated to KLH.
Specificity	CD20 Monoclonal Antibody detects endogenous levels of CD20 protein.
Gene Name	MS4A1
Protein Name	B-lymphocyte antigen CD20
Other Name	MS4A1; / CD20; / B-lymphocyte antigen CD20; / B-lymphocyte surface antigen B1; / Bp35; / Leukocyte surface antigen Leu-16; / Membrane-spanning 4-domains subfamily A member 1; / CD antigen CD20
Species	Human
Gene ID	931
Uniprot	P11836,
Species.1	Mouse
Gene ID.1	12482
Uniprot.1	P19437
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein . Cell membrane; Lipid-anchor . Constitutively associated with membrane rafts. .
Tissue Expression	Expressed on B-cells.
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas	>>Hematopoietic cell lineage
Function	Caution:Epitope 1, mapped in PubMed:16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained.,Function:This protein may be involved in the regulation of B-cell activation and proliferation.,online information:CD20 entry,pharmaceutical:Monoclonal antibodies(mAb) against CD20 are used to treat B-cell non-Hodgkin's lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity.,PTM:Phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Belongs to the MS4A family.,tissue specificity:Expressed on B-cells.,