CD24 Polyclonal Antibody
Ucallm_WP11487-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],
Specifications
| Size | 50μL/100μL |
| Target | CD24 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35,45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CD24. AA range:14-63 |
| Specificity | CD24 Polyclonal Antibody detects endogenous levels of CD24 protein. |
| Gene Name | CD24 |
| Protein Name | Signal transducer CD24 |
| Other Name | CD24; / CD24A; / Signal transducer CD24; / Small cell lung carcinoma cluster 4 antigen; / CD antigen CD24 |
| Species | Human |
| Gene ID | 100133941 |
| Uniprot | P25063, |
| Species.1 | Mouse |
| Gene ID.1 | 12484 |
| Uniprot.1 | P24807, |
| Species.2 | Rat |
| Gene ID.2 | 25145 |
| Uniprot.2 | Q07490 |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Expression | B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage |
| Research Areas | >>Hematopoietic cell lineage |
| Function | Disease:Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.,Function:Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.,induction:Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.,PTM:Extensively O-glycosylated.,similarity:Belongs to the CD24 family.,subunit:Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.,tissue specificity:B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells., |
Please login to post questions
Related products
