CD3 [PTR1374] recombinant mouse mAb
Ucallm_WM1325-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded byThis gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex.This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects inThis gene cause immunodeficiency.This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Specifications
| Size | 50μL/100μL |
| Target | CKR-5 |
| Reactivity | Human |
| Applications | FC, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | Please check the information on the tube |
| Clonality | Monoclonal |
| Clone Number | RMMR1381 |
| Immunogen | Purified recombinant Human CD3 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD3 protein. |
| Gene Name | CD3E T3E |
| Protein Name | T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e) |
| Other Name | T-cell surface glycoprotein CD3 epsilon chain; / T-cell surface antigen T3/Leu-4 epsilon chain; / CD antigen CD3e; / CD3 nanobody |
| Species | Human |
| Gene ID | 916 |
| Uniprot | P07766 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency |
| Research Areas | >>Viral life cycle - HIV-1; / >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>Endocytosis; / >>Toxoplasmosis; / >>Human cytomegalovirus infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Human immunodeficiency virus 1 infection; / >>Viral carcinogenesis |
| Function | The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta., |
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