CD32-A Polyclonal Antibody
Ucallm_WP11499-50
Price range: $268.00 through $328.00
Product details
Background:
Fc fragment of IgG receptor IIa(FCGR2A) Homo sapiens This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD32 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FCGR2A. AA range:241-290 |
| Specificity | CD32-A Polyclonal Antibody detects endogenous levels of CD32-A protein. |
| Gene Name | FCGR2A |
| Protein Name | Low affinity immunoglobulin gamma Fc region receptor II-a |
| Other Name | FCGR2A; / CD32; / FCG2; / FCGR2A1; / IGFR2; / Low affinity immunoglobulin gamma Fc region receptor II-a; / IgG Fc receptor II-a; / CDw32; / Fc-gamma RII-a; / Fc-gamma-RIIa; / FcRII-a; / CD antigen CD32 |
| Species | Human |
| Gene ID | 2212 |
| Uniprot | P12318 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Found on monocytes, neutrophils and eosinophil platelets. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Immune disease >> Systemic lupus erythematosus |
| Research Areas | >>Phagosome; / >>Osteoclast differentiation; / >>Platelet activation; / >>Neutrophil extracellular trap formation; / >>Fc gamma R-mediated phagocytosis; / >>Pathogenic Escherichia coli infection; / >>Yersinia infection; / >>Leishmaniasis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Coronavirus disease - COVID-19; / >>Systemic lupus erythematosus |
| Function | Function:Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function.,tissue specificity:Found on monocytes, neutrophils and eosinophil platelets., |
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