Price range: $268.00 through $328.00
Background:
CD35, also known as complement receptor 1, is a membrane penetrating glycoprotein with a molecular weight of 210-220 kDa, which can bind to complement C3b and C4b. CD35 is expressed in follicular dendritic cells, mature B lymphocytes, monocytes, erythrocytes, glomerular podocytes and some T cells. It is mainly used for the study of follicular dendritic cells and their derived tumors.
| Size | 50μL/100μL |
| Target | CD35 |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 223kD |
| MW(Observed) | 250kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-CD35 |
| Immunogen | Synthesized peptide derived from human CD35 AA range: 300-400 |
| Specificity | The antibody can specifically recognize human CD35 protein. |
| Gene Name | CR1 C3BR |
| Protein Name | Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35) |
| Other Name | C3 binding protein; / C3b/C4b receptor; / C3BR; / C4BR; / CD 35; / CD35; / CD35 antigen; / complement component; / 3b/4b; / receptor 1; / Knops blood group; / complement component; / 3b/4b; / receptor 1 including Knops blood group system; / Complement component receptor 1; / Complement receptor 1; / Complement receptor type 1; / CR 1; / CR1; / CR1_HUMAN; / KN; / Knops blood group antigen |
| Species | Human |
| Gene ID | 1378 |
| Uniprot | P17927 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Complement and coagulation cascades;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation |
| Research Areas | >>Complement and coagulation cascades; / >>Neutrophil extracellular trap formation; / >>Hematopoietic cell lineage; / >>Legionellosis; / >>Leishmaniasis; / >>Malaria; / >>Tuberculosis |
| Function | Function:Mediates cellular binding of particles and immune complexes that have activated complement.,miscellaneous:This is the sequence of the F allotype of CR1.,online information:Blood group antigen gene mutation database,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 30 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells., |
