Name: CD36 [PTR1384] recombinant mouse mAb
SKU: WM1252
Price: 268 USD
Availability: InStock

Product details

Background:
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014],

Specifications

Target	CD3
Reactivity	Human
Applications	FC, ELISA
MW(Calculated)	90kD
MW(Observed)
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Formulation	Phosphate-buffered solution
Source
Purification	Recombinant Expression and Affinity purified
Purity
Storage	-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration	Please check the information on the tube
Clonality	Monoclonal
Clone Number	PTR1378
Immunogen	Purified recombinant human CD36
Sequence
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD36 protein.
Gene Name	CD36
Protein Name	Platelet glycoprotein 4
Other Name	CD36; / GP3B; / GP4; / Platelet glycoprotein 4; / Fatty acid translocase; / FAT; / Glycoprotein IIIb; / GPIIIB; / Leukocyte differentiation antigen CD36; / PAS IV; / PAS-4; / Platelet collagen receptor; / Platelet glycoprotein IV; / GPIV; / Thrombospondin receptor; / CD36
Species	Human
Gene ID-1	916
Uniprot	P16671,
Species.1	Mouse
Gene ID-2	12491
Uniprot.1	Q08857
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014],
Cellular Localization	Cell membrane; Multi-pass membrane protein . Membrane raft . Golgi apparatus . Apical cell membrane . Upon ligand-binding, internalized through dynamin-dependent endocytosis. .
Tissue Expression	Membranous
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency
Research Areas
Function	Disease:Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.,Disease:Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].,Function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.,online information:CD36 entry,polymorphism:Genetic variation in CD36 influences the severity and outcome of malaria infection.,PTM:N-glycosylated and O-glycosylated with a ratio of 2:1.,similarity:Belongs to the CD36 family.,
RRID