Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011],
| Size | 50μL/100μL |
| Target | CD43 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | 44kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CD43 AA range: 1-80 |
| Specificity | This antibody detects endogenous levels of Human CD43 |
| Gene Name | SPN CD43 |
| Protein Name | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] |
| Other Name | Leukosialin; / Galactoglycoprotein; / GALGP; / Leukocyte sialoglycoprotein; / Sialophorin; / CD antigen CD43 |
| Species | Human |
| Gene ID | 6693 |
| Uniprot | P16150, |
| Species.1 | Mouse |
| Gene ID.1 | 20737 |
| Uniprot.1 | P15702, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P13838 |
| Cellular Localization | Membrane; Single-pass type I membrane protein . Cell projection, microvillus . Cell projection, uropodium . Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). .; [CD43 cytoplasmic tail]: Nucleus . Nucleus, PML body . The sumoylated form localizes to the PML body. . |
| Tissue Expression | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules |
| Function | Disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,Function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.,subunit:Interacts with HIPK2 via the cytoplasmic domain.,tissue specificity:Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas., |
