Need Help? +(1)-866-986-9598
0 My Cart$0.00
Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CD54 [ABT-CD54] mouse mAb
SKU: WM1389 Categories: ,

CD54 [ABT-CD54] mouse mAb

Ucallm_WM1389-50

Price range: $268.00 through $328.00

SKU: WM1389-50
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:
CD54, also known as ICAM-1, is a type I transmembrane protein. CD is expressed on activated endothelial cells, high endothelial venules, monocytes/macrophages, T and B cells, dendritic cells and granulocytes. It plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 is also detected in some carcinoma and melanoma cells. In patients with various inflammatory syndromes, the level of soluble CD54 is upregulated in plasma.

Specifications

Size50μL/100μL
TargetCD54
ReactivityHuman
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)58kD
MW(Observed)100kD
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM-CD54
ImmunogenSynthesized peptide derived from human CD54 AA range: 100-200
SpecificityThe antibody can specifically recognize human CD54 protein.
Gene NameICAM1
Protein NameIntercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Other NameAntigen identified by monoclonal BB2; / BB 2; / BB2; / CD 54; / CD_antigen=CD54; / CD54; / Cell surface glycoprotein P3.58; / Human rhinovirus receptor; / ICAM 1; / ICAM-1; / ICAM1; / ICAM1_HUMAN; / intercellular adhesion molecule 1; / CD54; / intercellular adhesion molecule 1; / CD54; / , human rhinovirus receptor; / Intercellular adhesion molecule 1; / Major group rhinovirus receptor; / MALA 2; / MALA2; / MyD 10; / MyD10; / P3.58; / Surface antigen of activated B cells; / Surface antigen of activated B cells, BB2
SpeciesHuman
Gene ID3383
UniprotP05362
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembranous
Tissue ExpressionBlood,Kidney,Liver,Melanoma,Plasma,
Signaling_pathwayOrganismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas>>NF-kappa B signaling pathway; / >>Cell adhesion molecules; / >>Natural killer cell mediated cytotoxicity; / >>TNF signaling pathway; / >>Leukocyte transendothelial migration; / >>AGE-RAGE signaling pathway in diabetic complications; / >>African trypanosomiasis; / >>Malaria; / >>Staphylococcus aureus infection; / >>Influenza A; / >>Human T-cell leukemia virus 1 infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Epstein-Barr virus infection; / >>Rheumatoid arthritis; / >>Viral myocarditis; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis
FunctionFunction:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,
Please login to post questions

Related products

Western blot analysis of lysates from Hela cells, using Clathrin Heavy Chain 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4016
Categories: ,

U-Blot® Tuberin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4011
Categories: ,

U-Blot® Smad2 (Phospho Ser250) Rabbit mAb

0 Reviews
Price range: $288.00 through $368.00
Select options
Western blot analysis of lysates from NIH-3T3 cells, using GCLM Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4015
Categories: ,

U-Blot® MMP7 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4003
Categories: ,

U-Blot® PMS2 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4004
Categories: ,

U-Blot® Cleaved PARP1 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Mouse lung whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Sku: WR4002
Categories: ,

U-Blot® Ezrin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options

Customer Reviews

  • Shop Categories
Menu
Need Help? +(1)-866-986-9598
Back to Top
Product has been added to your cart