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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/CD79b Polyclonal Antibody
SKU: WP15326 Categories: ,

CD79b Polyclonal Antibody

Ucallm_WP15326-50

Price range: $268.00 through $328.00

SKU: WP15326-100
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Product details

Background:

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD79b
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)37kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD79B. AA range:61-110
SpecificityCD79b Polyclonal Antibody detects endogenous levels of CD79b protein.
Gene NameCD79B
Protein NameB-cell antigen receptor complex-associated protein beta chain
Other NameCD79B; / B29; / IGB; / B-cell antigen receptor complex-associated protein beta chain; / B-cell-specific glycoprotein B29; / Ig-beta; / Immunoglobulin-associated B29 protein; / CD79b
SpeciesHuman
Gene ID974
UniprotP40259,
Species.1Mouse
Gene ID.1
Uniprot.1P15530
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .
Tissue ExpressionB-cells.
Signaling_pathwayOrganismal Systems >> Immune system >> B cell receptor signaling pathway
Research Areas>>B cell receptor signaling pathway
FunctionDisease:Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells.,Function:Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.,online information:CD79B mutation db,PTM:Phosphorylated on tyrosine upon B-cell activation.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.,subunit:Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.,tissue specificity:B-cells.,
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