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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CD94 Monoclonal Antibody
SKU: WM0108 Categories: ,

CD94 Monoclonal Antibody

Ucallm_WM0108-50

Price range: $268.00 through $328.00

SKU: WM0108-50
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Product details

Background:
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

TargetCD94
ReactivityHuman
ApplicationsWB, FC, ELISA
MW(Calculated)21kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-1:2000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationAffinity purification
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number3H10
ImmunogenPurified recombinant fragment of human CD94 expressed in E. Coli.
Sequence
SpecificityCD94 Monoclonal Antibody detects endogenous levels of CD94 protein.
Gene NameKLRD1
Protein NameNatural killer cells antigen CD94
Other NameKLRD1; / CD94; / Natural killer cells antigen CD94; / KP43; / Killer cell lectin-like receptor subfamily D member 1; / NK cell receptor; / CD antigen CD94
SpeciesHuman
Gene ID-13824
UniprotQ13241,
Species.1Mouse
Gene ID-2
Uniprot.1O54707
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundNatural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Cellular LocalizationCell membrane; Single-pass type II membrane protein .
Tissue ExpressionExpressed in NK cell subsets (at protein level) (PubMed:21825173, PubMed:9430220, PubMed:9485206). Expressed in memory/effector CD8-positive alpha-beta T cell subsets (at protein level) (PubMed:12387742, PubMed:20952657). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:20952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657).
Signaling_pathwayOrganismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Antigen processing and presentation;Human Diseases >> Immune disease >> Graft-versus-host disease
Research Areas>>Antigen processing and presentation; / >>Natural killer cell mediated cytotoxicity; / >>Graft-versus-host disease
FunctionFunction:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.,online information:CD94,similarity:Contains 1 C-type lectin domain.,subunit:Can form disulfide-bonded heterodimer with NKG2 family members.,tissue specificity:Natural killer cells.,
RRID
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