Price range: $268.00 through $328.00
Background:
UDP glycosyltransferase 8(UGT8) Homo sapiens The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011],
| Size | 50μL/100μL |
| Target | CGT |
| Reactivity | Human, Rat |
| Applications | IHC, IF, WB |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; WB 1:500-2000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CGT |
| Specificity | This antibody detects endogenous levels of human CGT |
| Gene Name | UGT8 CGT UGT4 |
| Protein Name | CGT |
| Other Name | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; / Ceramide UDP-galactosyltransferase; / Cerebroside synthase; / UDP-galactose-ceramide galactosyltransferase |
| Species | Human |
| Gene ID | 7368 |
| Uniprot | Q16880 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass membrane protein . Endoplasmic reticulum . |
| Tissue Expression | Brain, |
| Signaling_pathway | |
| Research Areas | >>Ether lipid metabolism; / >>Sphingolipid metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.,Function:Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.,online information:2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor,pathway:Sphingolipid metabolism; galactosylceramide biosynthesis.,similarity:Belongs to the UDP-glycosyltransferase family., |
