CHP Polyclonal Antibody
Ucallm_WP11622-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CHP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 24kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human CHP. |
| Specificity | CHP Polyclonal Antibody detects endogenous levels of CHP protein. |
| Gene Name | CHP1 |
| Protein Name | Calcineurin B homologous protein 1 |
| Other Name | CHP1; / CHP; / Calcineurin B homologous protein 1; / Calcineurin B-like protein; / Calcium-binding protein CHP; / Calcium-binding protein p22; / EF-hand calcium-binding domain-containing protein p22 |
| Species | Human |
| Gene ID | 11261 |
| Uniprot | Q99653, |
| Species.1 | Mouse |
| Gene ID.1 | 56398 |
| Uniprot.1 | P61022, |
| Species.2 | Rat |
| Gene ID.2 | 64152 |
| Uniprot.2 | P61023 |
| Cellular Localization | Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Endomembrane system . Endoplasmic reticulum-Golgi intermediate compartment . Endoplasmic reticulum . Cell membrane . Membrane; Lipid-anchor . Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane. . |
| Tissue Expression | Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Required for constitutive membrane traffic. Inhibits GTPase-stimulated Na(+)/H(+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.,PTM:Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic.,PTM:Phosphorylated; decreased phosphorylation is associated with an increase in exchange activity. The phosphorylation state may regulate the binding to NHE1.,similarity:Contains 4 EF-hand domains.,subunit:Monomer (By similarity). Specifically binds to SLC9A1/NHE1 at a domain that is critical for growth factor stimulation of exchange activity.,tissue specificity:Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen., |
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