CHP2 Polyclonal Antibody
Ucallm_WP11623-50
Price range: $268.00 through $328.00
Product details
Background:
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | CHP2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHP2. AA range:101-150 |
| Specificity | CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein. |
| Gene Name | CHP2 |
| Protein Name | Calcineurin B homologous protein 2 |
| Other Name | CHP2; / HCA520; / Calcineurin B homologous protein 2; / Hepatocellular carcinoma-associated antigen 520 |
| Species | Human |
| Gene ID | 63928 |
| Uniprot | O43745, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9D869, |
| Species.2 | Rat |
| Gene ID.2 | 308965 |
| Uniprot.2 | Q810D1 |
| Cellular Localization | Nucleus . Cytoplasm . Cell membrane . Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. . |
| Tissue Expression | Expressed in malignantly transformed cells but not detected in normal tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death.,similarity:Contains 4 EF-hand domains.,subunit:Binds to SLC9A1/NHE1.,tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues., |
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