CIB2 Polyclonal Antibody
Ucallm_WP11633-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Specifications
| Size | 50μL/100μL |
| Target | CIB2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CIB2. AA range:21-70 |
| Specificity | CIB2 Polyclonal Antibody detects endogenous levels of CIB2 protein. |
| Gene Name | CIB2 |
| Protein Name | Calcium and integrin-binding family member 2 |
| Other Name | CIB2; / KIP2; / Calcium and integrin-binding family member 2; / Kinase-interacting protein 2; / KIP 2 |
| Species | Human |
| Gene ID | 10518 |
| Uniprot | O75838, |
| Species.1 | Mouse |
| Gene ID.1 | 56506 |
| Uniprot.1 | Q9Z309, |
| Species.2 | Rat |
| Gene ID.2 | 300719 |
| Uniprot.2 | Q568Z7 |
| Cellular Localization | Cytoplasm . Cell projection, stereocilium . Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Cell membrane, sarcolemma . Colocalized with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (PubMed:26173970, PubMed:26426422). . |
| Tissue Expression | Widely expressed (PubMed:23023331). |
| Signaling_pathway | |
| Research Areas | |
| Function | similarity:Contains 3 EF-hand domains.,tissue specificity:Ubiquitous., |
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