Name: Citron Polyclonal Antibody
SKU: WP11639
Price: 268 USD
Availability: InStock

Citron Polyclonal Antibody

Ucallm_WP11639-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP11639-100

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Product details

Background:

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Specifications

Size	50μL/100μL
Target	Citron
Reactivity	Human, Mouse
Applications	IHC, IF, ELISA
MW(Calculated)	231kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human CTRO. AA range:1011-1060
Specificity	Citron Polyclonal Antibody detects endogenous levels of Citron protein.
Gene Name	CIT
Protein Name	Citron Rho-interacting kinase
Other Name	CIT; / CRIK; / KIAA0949; / STK21; / Citron Rho-interacting kinase; / CRIK; / Serine/threonine-protein kinase 21
Species	Human
Gene ID	11113
Uniprot	O14578,
Species.1	Mouse
Gene ID.1
Uniprot.1	P49025
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm .
Tissue Expression	Brain,Epithelium,
Signaling_pathway
Research Areas
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 CNH domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer.,

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Citron Polyclonal Antibody

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Citron Polyclonal Antibody

Product details

Specifications

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