CKAP2 rabbit pAb
Ucallm_WP4339-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013],
Specifications
| Size | 50μL/100μL |
| Target | CKAP2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 75kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CKAP2 AA range: 298-348 |
| Specificity | This antibody detects endogenous levels of CKAP2 at Human/Mouse |
| Gene Name | CKAP2 LB1 TMAP |
| Protein Name | CKAP2 |
| Other Name | |
| Species | Human |
| Gene ID | 26586 |
| Uniprot | Q8WWK9, |
| Species.1 | Mouse |
| Gene ID.1 | 80986 |
| Uniprot.1 | Q3V1H1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules. |
| Tissue Expression | Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C).,Function:Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.,induction:Up-regulated in primary human gastric cancers.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the CKAP2 family.,subcellular location:Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.,subunit:Associates with alpha- and beta-tubulins.,tissue specificity:Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney., |
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