CKR-3 Polyclonal Antibody
Ucallm_WP15355-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | CKR-3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 41kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR3. AA range:1-50 |
| Specificity | CKR-3 Polyclonal Antibody detects endogenous levels of CKR-3 protein. |
| Gene Name | CCR3 |
| Protein Name | C-C chemokine receptor type 3 |
| Other Name | CCR3; / CMKBR3; / C-C chemokine receptor type 3; / C-C CKR-3; / CC-CKR-3; / CCR-3; / CCR3; / CKR3; / Eosinophil eotaxin receptor; / CD193 |
| Species | Human |
| Gene ID | 1232 |
| Uniprot | P51677, |
| Species.1 | Mouse |
| Gene ID.1 | 12771 |
| Uniprot.1 | P51678, |
| Species.2 | Rat |
| Gene ID.2 | 117027 |
| Uniprot.2 | O54814 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | In eosinophils as well as trace amounts in neutrophils and monocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>Human cytomegalovirus infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Viral carcinogenesis |
| Function | Function:Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds to HIV-1 Tat.,tissue specificity:In eosinophils as well as trace amounts in neutrophils and monocytes., |
Please login to post questions
Related products
