Product details
Background:
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CL12B rabbit pAb
Ucallm_WP4138-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CL12B |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 30kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CL12B AA range: 111-161 |
| Specificity | This antibody detects endogenous levels of CL12B at Human/Mouse |
| Gene Name | CLEC12B UNQ5782/PRO16089 |
| Protein Name | CL12B |
| Other Name | |
| Species | Human |
| Gene ID | 387837 |
| Uniprot | Q2HXU8, |
| Species.1 | Mouse |
| Gene ID.1 | 71183 |
| Uniprot.1 | Q149M0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein . |
| Tissue Expression | Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis (PubMed:17562706). Expressed in melanocytes (at protein level) (PubMed:34310951). |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,Function:Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,Function:Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,induction:Down-regulated in activated leukocytes recruited to a site of inflammation.,PTM:Highly N-glycosylated. Glycosylation varies between cell types.,similarity:Contains 1 C-type lectin domain.,subcellular location:Ligand binding leads to internalization.,subunit:Homodimer. Interacts with PTPN6 and PTPN11.,subunit:Interacts with PTPN6 and PTPN11.,tissue specificity:Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.,tissue specificity:Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages., |
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