Claudin 11 Antibody
Ucallm_WP16025-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
Specifications
| Size | 50μL/100μL |
| Target | Claudin 11 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 20kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Claudin 11 |
| Specificity | This antibody detects endogenous levels of Claudin 11 Antibody |
| Gene Name | CLDN11 OSP OTM |
| Protein Name | Claudin-11 (Oligodendrocyte-specific protein) |
| Other Name | Claudin-11; / Oligodendrocyte-specific protein |
| Species | Human |
| Gene ID | 5010 |
| Uniprot | O75508, |
| Species.1 | Mouse |
| Gene ID.1 | 18417 |
| Uniprot.1 | Q60771, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q99P82 |
| Cellular Localization | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Lung,Spinal cord, |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C |
| Function | Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Interacts with tetraspanin-3/TSPAN3., |
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