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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Claudin-17 Polyclonal Antibody
SKU: WP15223 Categories: ,

Claudin-17 Polyclonal Antibody

Ucallm_WP15223-50

Price range: $268.00 through $328.00

SKU: WP15223-100
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Product details

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010],

Specifications

Size50μL/100μL
TargetClaudin-17
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)24kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from Claudin-17 . at AA range: 150-230
SpecificityClaudin-17 Polyclonal Antibody detects endogenous levels of Claudin-17 protein.
Gene NameCLDN17
Protein NameClaudin-17
Other NameCLDN17; / Claudin-17
SpeciesHuman
Gene ID26285
UniprotP56750,
Species.1Mouse
Gene ID.1239931
Uniprot.1Q8BXA6
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell junction, tight junction . Cell membrane; Multi-pass membrane protein .
Tissue ExpressionIn the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas>>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C
FunctionFunction:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,
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