Name: Claudin 7 [ABT441] mouse mAb
SKU: WM1410
Price: 268 USD
Availability: InStock

Claudin 7 [ABT441] mouse mAb

Ucallm_WM1410-50

Price range: $268.00 through $328.00

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SKU: WM1410-50

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Product details

Background:
Claudin 7 is a 22 kDa membrane protein, belonging to the tight junction protein family. Claudin family proteins play an important role in cell polarity, signal transduction and the pathogenesis of a variety of malignant tumors. It has been reported that compared with non neoplastic mucosal tissues, the expression of claudin 7 in laryngeal squamous cell carcinoma is down-regulated, and the expression level is related to distant metastasis, which can be used as a potential predictor of poor prognosis. Therefore, claudin 7 may be a useful immunohistochemical marker for the diagnosis, metastasis and prognosis of laryngeal cancer.

Specifications

Size	50μL/100μL
Target	Claudin 7
Reactivity	Human, Mouse, Rat
Applications	IHC, WB, IF, ELISA
MW(Calculated)	22kD
MW(Observed)	22kD
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM441
Immunogen	Synthesized peptide derived from human Claudin 7 AA range: 100-211
Specificity	The antibody can specifically recognize human Claudin 7 protein. In western blotting of LnCap cell lysate, the antibody can label a 22 kDa band corresponding to Claudin 7.
Gene Name	CLDN7 CEPTRL2 CPETRL2
Protein Name	Claudin-7
Other Name	CEPTR L2; / CEPTRL 2; / CEPTRL2; / Claudin 1; / Claudin 7; / Claudin 9; / Claudin-7; / Claudin1; / Claudin7; / Claudin9; / CLD7_HUMAN; / CLDN 7; / CLDN-7; / CLDN7; / Clostridium perfringens enterotoxin receptor like 2; / CPETR L2; / CPETRL 2; / CPETRL2; / Hs.84359
Species	Human
Gene ID	1366
Uniprot	O95471,
Species.1	Mouse
Gene ID.1	53624
Uniprot.1	Q9Z261,
Species.2	Rat
Gene ID.2	65132
Uniprot.2	Q9Z1L1
Cellular Localization	Membranous
Tissue Expression	kindey
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C
Function	Function:Plays a major role in tight junction-specific obliteration of the intercellular space.,induction:By androgens.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,tissue specificity:Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.,

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Claudin 7 [ABT441] mouse mAb

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Claudin 7 [ABT441] mouse mAb

Product details

Specifications

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