CLC-4 Polyclonal Antibody
Ucallm_WP11665-50
Price range: $268.00 through $328.00
Product details
Background:
chloride voltage-gated channel 4(CLCN4) Homo sapiens The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012],
Specifications
| Size | 50μL/100μL |
| Target | CLC-4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CLCN4. AA range:221-270 |
| Specificity | CLC-4 Polyclonal Antibody detects endogenous levels of CLC-4 protein. |
| Gene Name | CLCN4 |
| Protein Name | H(+)/Cl(-) exchange transporter 4 |
| Other Name | CLCN4; / H; / +; / /Cl; / -; / exchange transporter 4; / Chloride channel protein 4; / ClC-4; / Chloride transporter ClC-4 |
| Species | Human |
| Gene ID | 1183 |
| Uniprot | P51793, |
| Species.1 | Mouse |
| Gene ID.1 | 12727 |
| Uniprot.1 | Q61418, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P51794 |
| Cellular Localization | Early endosome membrane; Multi-pass membrane protein . Late endosome membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Lysosome membrane; Multi-pass membrane protein . Recycling endosome membrane; Multi-pass membrane protein . Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3. . |
| Tissue Expression | Abundant in skeletal muscle and also detectable in brain and heart. |
| Signaling_pathway | Organismal Systems >> Immune system >> Neutrophil extracellular trap formation |
| Research Areas | >>Neutrophil extracellular trap formation |
| Function | Function:Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.,miscellaneous:The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,tissue specificity:Abundant in skeletal muscle and also detectable in brain and heart., |
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