SKU: WP2323 Categories: ,

CLC10 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2323-100
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Product details

Background:

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],

Specifications

TargetCLC10
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000; IF 1:100-300; ELISA 1:5000-20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein AA range: 191-240
Sequence
SpecificityCLC10 Polyclonal Antibody detects endogenous levels of protein.
Gene NameCLEC10A CLECSF13 CLECSF14 HML
Protein NameC-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301)
Other Name
SpeciesHuman
Gene ID-110462
UniprotQ8IUN9,
Species.1Mouse
Gene ID-2
Uniprot.1P49300,
Species.2Rat
Gene ID-3
Uniprot.2P49301
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Cellular LocalizationMembrane; Single-pass type II membrane protein .
Tissue ExpressionBrain,Peripheral blood monocyte,Testis,
Signaling_pathway
Research Areas
FunctionFunction:Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.,online information:MGL,similarity:Contains 1 C-type lectin domain.,
RRID
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