CNOT7 Polyclonal Antibody
Ucallm_WP11701-50
Price range: $268.00 through $328.00
Product details
Background:
CCR4-NOT transcription complex subunit 7(CNOT7) Homo sapiens The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016],
Specifications
| Size | 50μL/100μL |
| Target | CNOT7 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNOT7. AA range:10-59 |
| Specificity | CNOT7 Polyclonal Antibody detects endogenous levels of CNOT7 protein. |
| Gene Name | CNOT7 |
| Protein Name | CCR4-NOT transcription complex subunit 7 |
| Other Name | CNOT7; / CAF1; / CCR4-NOT transcription complex subunit 7; / BTG1-binding factor 1; / CCR4-associated factor 1; / CAF-1 |
| Species | Human |
| Gene ID | 29883 |
| Uniprot | Q9UIV1, |
| Species.1 | Mouse |
| Gene ID.1 | 18983 |
| Uniprot.1 | Q60809 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Cytoplasm, P-body . NANOS2 promotes its localization to P-body. . |
| Tissue Expression | Embryo,Lymph,Placenta,Prostate,Testis, |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> RNA degradation |
| Research Areas | >>RNA degradation |
| Function | Function:Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.,similarity:Belongs to the CAF1 family.,subunit:Interacts with TOB1., |
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