CRF-RII Polyclonal Antibody
Ucallm_WP11798-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],
Specifications
| Size | 50μL/100μL |
| Target | CRHR2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 48kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CRHR2. AA range:71-120 |
| Specificity | CRF-RII Polyclonal Antibody detects endogenous levels of CRF-RII protein. |
| Gene Name | CRHR2 CRF2R CRH2R |
| Protein Name | Corticotropin-releasing factor receptor 2 |
| Other Name | CRHR2; / CRF2R; / CRH2R; / Corticotropin-releasing factor receptor 2; / CRF-R-2; / CRF-R2; / CRFR-2; / Corticotropin-releasing hormone receptor 2; / CRH-R-2; / CRH-R2 |
| Species | Human |
| Gene ID | 1395 |
| Uniprot | Q13324, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q60748, |
| Species.2 | Rat |
| Gene ID.2 | 64680 |
| Uniprot.2 | P47866 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Amygdala,Brain,Skeletal muscle, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Cushing syndrome |
| Function | Function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family., |
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