Name: CSK mouse mAb
SKU: WM0635
Price: 268 USD
Availability: InStock

CSK mouse mAb

Ucallm_WM0635-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM0635-50

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Product details

Background:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., function:Specifically phosphorylates ‘Tyr-504’ on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases., PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 SH3 domain., subcellular location:Mainly cytoplasmic, also present in lipid rafts., subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1., tissue specificity:Expressed in lung and macrophages.,

Specifications

Size	50μL/100μL
Target	CSK
Reactivity	Human, Rat
Applications	WB, ICC
MW(Calculated)
MW(Observed)	50kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000; ICC 1:50
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	12C8
Immunogen	Purified recombinant human Csk protein fragments expressed in E.coli.
Specificity	This antibody detects endogenous levels of Csk and does not cross-react with related proteins.
Gene Name	csk
Protein Name
Other Name	C SRC; / C SRC kinase; / C src Tyrosine Kinase; / C-SRC kinase; / c-src tyrosine kinase; / Csk A; / CSK; / CSK_HUMAN; / CYTOPLASMIC TYROSINE KINASE; / MGC112926; / MGC117393; / MGC154049; / P60 Src; / Protein tyrosine kinase CYL; / Protein-tyrosine kinase CYL; / Proto oncogene tyrosine protein kinase; / Tyrosine protein kinase CSK; / Tyrosine protein kinase CSK; / Tyrosine-protein kinase CSK; / zgc:154049.
Species	Human
Gene ID	1445
Uniprot	P41240,
Species.1	Mouse
Gene ID.1	12988
Uniprot.1	P41241
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
Tissue Expression	Expressed in lung and macrophages.
Signaling_pathway
Research Areas	>>Epithelial cell signaling in Helicobacter pylori infection
Function	Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,