Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011],
| Size | 50μL/100μL |
| Target | CUX1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 164kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CUTL1. AA range:10-59 |
| Specificity | CUX1 Polyclonal Antibody detects endogenous levels of CUX1 protein. |
| Gene Name | CUX1 |
| Protein Name | Homeobox protein cut-like 1/Protein CASP |
| Other Name | CUX1; / CUTL1; / Homeobox protein cut-like 1; / CCAAT displacement protein; / CDP; / Homeobox protein cux-1; / CUX1; / CUTL1; / Protein CASP |
| Species | Human |
| Gene ID | 1523 |
| Uniprot | P39880;Q13948, |
| Species.1 | Mouse |
| Gene ID.1 | 13047;13047 |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Colon,Duodenum,Liver,Umbilical vein, |
| Signaling_pathway | |
| Research Areas | |
| Function | Alternative products:Additional isoforms seem to exist,Function:May be involved in intra-Golgi retrograde transport.,Function:Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer.,miscellaneous:Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CASP family.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 3 CUT DNA-binding domains.,subunit:Homodimer; disulfide-linked. Interacts with GOLGA5.,subunit:Interacts with BANP., |
