Cyclin D3 Monoclonal Antibody
Ucallm_WM0132-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
Specifications
| Size | 50μL/100μL |
| Target | Cyclin D3 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | 33kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 13D3 |
| Immunogen | Purified recombinant fragment of human Cyclin D3 expressed in E. Coli. |
| Specificity | Cyclin D3 Monoclonal Antibody detects endogenous levels of Cyclin D3 protein. |
| Gene Name | CCND3 |
| Protein Name | G1/S-specific cyclin-D3 |
| Other Name | CCND3; / G1/S-specific cyclin-D3 |
| Species | Human |
| Gene ID | 896 |
| Uniprot | P30281, |
| Species.1 | Mouse |
| Gene ID.1 | 12445 |
| Uniprot.1 | P30282 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . |
| Tissue Expression | Brain,Lung,Placenta,Synovial membrane tissue,Umbilical cord blood, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cell cycle;Cellular Processes >> Cell growth and death >> p53 signaling pathway;Cellular Processes >> Cell growth and death >> Cellular senescence;Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>Cell cycle; / >>p53 signaling pathway; / >>PI3K-Akt signaling pathway; / >>Cellular senescence; / >>Wnt signaling pathway; / >>Hippo signaling pathway; / >>Focal adhesion; / >>JAK-STAT signaling pathway; / >>Measles; / >>Influenza A; / >>Human papillomavirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Pathways in cancer; / >>Viral carcinogenesis; / >>Chemical carcinogenesis - receptor activation |
| Function | Function:Essential for the control of the cell cycle at the G1/S (start) transition. Potentiates the transcriptional activity of ATF5.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin D subfamily.,subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K., |
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