SKU: WP11893 Categories: ,

CYP2S1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11893-100
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Product details

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCYP2S1
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)56kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230
SpecificityCYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein.
Gene NameCYP2S1
Protein NameCytochrome P450 2S1
Other NameCYP2S1; / Cytochrome P450 2S1; / CYPIIS1
SpeciesHuman
Gene ID29785
UniprotQ96SQ9,
Species.1Mouse
Gene ID.174134
Uniprot.1Q9DBX6
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum membrane; Peripheral membrane protein . Microsome membrane; Peripheral membrane protein .
Tissue ExpressionExpressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).
Signaling_pathway
Research Areas>>Retinol metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Metabolic pathways
FunctionCatalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,Function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen.,
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