SKU: WP11908 Categories: ,

CYP4X1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11908-100
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Product details

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

Specifications

Size50μL/100μL
TargetCYP4X1
ReactivityHuman, Monkey
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)50kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human Cytochrome P450 4X1. AA range:251-300
SpecificityCYP4X1 Polyclonal Antibody detects endogenous levels of CYP4X1 protein.
Gene NameCYP4X1
Protein NameCytochrome P450 4X1
Other NameCYP4X1; / Cytochrome P450 4X1; / CYPIVX1
SpeciesHuman
Gene ID260293
UniprotQ8N118
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum membrane; Single-pass membrane protein . Microsome membrane; Single-pass membrane protein .
Tissue ExpressionExpressed in brain, heart, kidney and skin and, at lower levels, in skeletal muscle and liver (PubMed:16478468, PubMed:18549450). In the brain, high levels are detected in amygdala and lower levels in globus pallidus and cerebellum (PubMed:18549450). In the heart, very high levels in aorta, but very low levels in other heart regions (PubMed:16478468, PubMed:18549450). Also expressed in breast, prostate and colon (PubMed:18549450).
Signaling_pathway
Research Areas>>Serotonergic synapse
FunctionCatalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,similarity:Belongs to the cytochrome P450 family.,
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