Price range: $268.00 through $328.00
Background:
Cytokeratin 13 (CK13) is a 54 kDa protein which belongs to the intermediate filament family. CK13 protein is highly expressed in normal tissues and gradually decreased or disappeared in malignant tissues. Defects in the CK13 gene may lead to white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia. CK13 can be used as an auxiliary indicator in the diagnosis of precancerous lesions.
| Size | 50μL/100μL |
| Target | Cytokeratin 13 |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 50kD |
| MW(Observed) | 50kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM057 |
| Immunogen | Synthesized peptide derived from human Cytokeratin 13 AA range: 400-458 |
| Specificity | The antibody can specifically recognize human CK13 protein. In western blotting of A431 cell lysate, the antibody can label a 50 kDa band corresponding to CK13. |
| Gene Name | KRT13 |
| Protein Name | 47 kDa cytokeratin; CK-13; CK13; Cytokeratin 13; Cytokeratin-13; K13; K1C13_HUMAN; Ka13; Keratin 13; Keratin; keratin type I cytoskeletal 13; Keratin-13; Krt-1.13; Krt1-13; KRT13; MGC161462; MGC3781; type I cytoskeletal 13; Type I keratin Ka13; WSN2 |
| Other Name | 47 kDa cytokeRatin; / CK-13; / CK13; / Cytokeratin 13; / CytokeRatin-13; / K13; / K1C13_HUMAN; / Ka13; / KeRatin 13; / KeRatin; / keRatin type I cytoskeletal 13; / KeRatin-13; / Krt-1.13; / Krt1-13; / KRT13; / MGC161462; / MGC3781; / type I cytoskeletal 13; / Type I keRatin Ka13; / WSN2 |
| Species | Human |
| Gene ID | 3860 |
| Uniprot | P13646, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P08730, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q6IFV4 |
| Cellular Localization | Cytoplasmic, Membranous |
| Tissue Expression | Tonsil |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Estrogen signaling pathway |
| Research Areas | >>Estrogen signaling pathway; / >>Staphylococcus aureus infection |
| Function | Disease:Defects in KRT13 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,online information:Keratin-13 entry,PTM:O-glycosylated; glycans consist of single N-acetylglucosamine residues.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.,tissue specificity:Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta., |
