Price range: $268.00 through $328.00
Background:This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
| Size | 50μL/100μL |
| Target | DARPP-32 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 23kD |
| MW(Observed) | 32kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0500R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | PPP1R1B |
| Protein Name | Protein phosphatase 1 regulatory subunit 1B |
| Other Name | PPP1R1B; / DARPP32; / Protein phosphatase 1 regulatory subunit 1B; / DARPP-32; / Dopamine- and cAMP-regulated neuronal phosphoprotein |
| Species | Human |
| Gene ID | 839 |
| Uniprot | Q9UD71, |
| Species.1 | Mouse |
| Gene ID.1 | 19049 |
| Uniprot.1 | Q60829, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O35397 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Lung,Lymphocyte,T-cell, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis |
| Research Areas | >>Apoptosis; / >>Lipid and atherosclerosis |
| Function | Function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family., |
