DCT Polyclonal Antibody
Ucallm_WP15804-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:L-dopachrome = 5, 6-dihydroxyindole-2-carboxylate., cofactor:Binds 2 zinc ions per subunit., function:Involved in regulating eumelanin and phaeomelanin levels., pathway:Pigment biosynthesis; melanin biosynthesis., similarity:Belongs to the tyrosinase family., subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,
Specifications
| Size | 50μL/100μL |
| Target | DCT |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 59kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 232-304 |
| Specificity | The antibody detects endogenous DCT |
| Gene Name | DCT TYRP2 |
| Protein Name | DCT |
| Other Name | L-dopachrome tautomerase; / DCT; / DT; / L-dopachrome Delta-isomerase; / Tyrosinase-related protein 2; / TRP-2; / TRP2 |
| Species | Human |
| Gene ID | 1638 |
| Uniprot | P40126, |
| Species.1 | Mouse |
| Gene ID.1 | 13190 |
| Uniprot.1 | P29812 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Melanosome membrane; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. . |
| Tissue Expression | Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma, |
| Signaling_pathway | |
| Research Areas | >>Tyrosine metabolism; / >>Metabolic pathways; / >>Melanogenesis |
| Function | Catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,Function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex., |
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